Topos Bio
Topos Bio is developing computational methods to drug intrinsically disordered proteins.
We're seeking a research scientist to develop and optimize ML methods that bridge simulation, protein modeling, and small molecule design. This role requires both strong machine learning foundations and the ability to work at the interface of computational biology, structural modeling, and chemistry.
What you will do
Develop generative models for protein conformational ensembles trained on simulation and experimental data
Build novel ML architectures for ensemble-based affinity prediction and generative chemistry
Adapt methods from research literature to disordered protein targets
Design scalable training pipelines for high-throughput experimentation
Collaborate with computational and experimental scientists to validate models against biophysical data
What we are looking for
Strong foundation in machine learning theory and implementation
Deep understanding of modern generative models with application to the sciences
Background in computational sciences involving biology and chemistry
Preferred
MS or PhD in machine learning with application to computational science
Strong publication record
Experience with molecular simulation and protein modeling
Summary
Develop and optimize machine learning methods bridging simulation, protein modeling, and small molecule design for disordered proteins. Build generative models for conformational ensembles, affinity prediction, and chemistry with scalable training pipelines. Requires ML foundations plus biology and chemistry background.
Responsibilities
Develop generative models for protein conformational ensembles trained on simulation and experimental data; build ML architectures for ensemble-based affinity prediction and generative chemistry; adapt literature methods to disordered targets; design scalable training pipelines
Qualifications
Strong foundation in machine learning theory and implementation; deep understanding of modern generative models with application to the sciences; background in computational sciences involving biology and chemistry; molecular simulation and protein modeling experience preferred
Education requirements
MS or PhD in machine learning with application to computational science preferred